Biochem/physiol Actions

Primary Target5-HT₆

General description

A high affinity 5-HT₆ Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT₆ receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664.Li, Z. et al. 2007. Brain Res.1134, 70.r>Hirst, et al. 2006. Eur. J. Pharm.553, 109. Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)